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Merck Confirms Data Leak in Melanoma Vaccine Trial With Moderna

Merck confirmed that data from its melanoma vaccine collaboration with Moderna was leaked. In the Phase 3 INTERPATH-001 trial, Intismeran combined with Keytruda reduced the risk of recurrence or death by 42% versus Keytruda alone, consistent with the leaked figures. Overall survival data remain immature but show a favorable trend for the combination, and no new safety signals were observed.

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AI take

The leak itself matters less than what it confirmed: the recurrence-free survival benefit held up against the disclosed figures, which lends the readout credibility even as the disclosure path raises governance questions for a late-stage program. The practical effect is on the competitive field around adjuvant melanoma, where a validated combination would reset expectations for rivals. Overall survival remains the unresolved piece — immature data with a favorable trend is not the same as demonstrated benefit, and whether that trend matures into a statistically meaningful result is the open question.

Generated by AI for reference only.

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