TREE NEWS update: Merck confirmed that data from its melanoma vaccine collaboration with Moderna was leaked. In the Phase 3 INTERPATH-001 trial, Intismeran combined with Keytruda reduced the risk of recurrence or death by 42% versus Keytruda alone, consistent with the leaked figures. Overall survival data remain immature but show a favorable trend for the combination, and no new safety signals were observed.
Merck Confirms Data Leak in Melanoma Vaccine Trial With Moderna
The leak itself matters less than what it confirmed: the recurrence-free survival benefit held up against the disclosed figures, which lends the readout credibility even as the disclosure path raises governance questions for a late-stage program. The practical effect is on the competitive field around adjuvant melanoma, where a validated combination would reset expectations for rivals. Overall survival remains the unresolved piece — immature data with a favorable trend is not the same as demonstrated benefit, and whether that trend matures into a statistically meaningful result is the open question.
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