TREE NEWS update: Baili Tianheng’s EGFR×HER3 bispecific antibody-drug conjugate Yizekang (iza-bren) was added to China’s 2026 National Reimbursement Drug List through national price negotiations, the list was announced on November 14 at the 2026 National Innovative Drug High-Quality Development Conference. The drug, the world’s first and only approved EGFR×HER3 bispecific ADC, entered reimbursement in its first year on the market under a new pre-declaration mechanism. The updated list takes effect January 1, 2027.
China’s 2026 National Reimbursement Drug List Adds Baili Tianheng’s EGFR×HER3 Bispecific ADC
The signal here is less about the drug than about process: a first-year product clearing reimbursement via a pre-declaration mechanism suggests China is shortening the path from approval to public coverage for genuinely novel modalities. For the bispecific ADC field, that sets a domestic precedent others will be measured against. Whether the mechanism widens to more first-in-class assets, and how negotiated pricing affects the commercial case for similar candidates, is the open question worth watching.
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